Evaluating ROR1 As a Target in Childhood Leukemia
نویسندگان
چکیده
منابع مشابه
GPI-Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications
Background: We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). Although FMOD has been considered as a cytoplasmic or secretory protein, we discovered the cell surface expression of FMOD in leukemic B cells via anchoring with glycosylphosphatidylinositol (GPI). Objective: To evaluate FM...
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Background: Acute lymphoblastic leukemia (ALL) results from genetic alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported to be increased in ALL and mantle cell lymphoma. In this study the expression of ROR1 was assessed in newly diagnosed patients with ALL. Methods: This study was carried out on 40 patients with newly diagnosed ALL and healthy individuals as contro...
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Bone marrow specimens from leukemic patients were studied in a 5 year period beginning in 1982 in Children's Medical Center of Teheran,a teaching and referral center for pediatric medicine. The slides were stained by Giemsa-Wright stains, read by at least two persons experienced in bone marrow pathology and classified according to F.A.B. recommendations. Peroxidase or Sudan black-B and P.A...
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Abstract Introduction Connection of socioeconomic status measures (such as income and education and parental addiction) to childhood leukemia are likely to vary with place and time. The aim of this study was to assess the relation between socioeconomic status and childhood leukemia. Materials and Methods a case- control study conducted on 86 case of acute lymphoblastic leukemia age 0-14 yea...
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conclusions the current study showed that breastfeeding duration has no protective effect against childhood leukemia and lymphoma. in addition, we suggest that some factors such as living in a rural area, smoking during pregnancy, parents’ exposure to chemical materials and low socioeconomic status can increase the incidence rate of childhood leukemia and lymphoma. results our findings showed t...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-126734